Can we leverage new technologies as Artificial Intelligence (AI) to enhance preservation of historical buildings and monuments, supporting restoration and conservation efforts in sites like Notre-Dame Cathedral in Paris and the Pisa Charterhouse? In response to this question, the book presents novel methodologies harnessing AI, semantic annotations and informative models for automatic classification of 3D survey data of historical buildings, integration and dissemination of information and semantic enrichment of digital representations. The presented tools enhance interpretation and accessibility of digital cultural heritage data, providing invaluable resources for restorers, engineers, architects, archaeologists, historians, and scholars in heritage sites conservation and preservation.